Anti-spermatogenic Effect of Hydro-ethanol Extract of Caesalpinia pulcherrima Leaves in Albino Rats
Pampa Lohar1, Tanusree Mondal1, Dibya Pal1, and Debidas Ghosh1,2∗
1Molecular Medicine, Nutrigenomics and Public Health Research Laboratory, Department of Bio-Medical Laboratory Science and Management,
Vidyasagar University, Midnapore 721 102, West Bengal, India
2Department of Medical Laboratory Technology, Debra Thana Sahid Kshudiram Smriti Mahavidyalaya, Debra, West Midnapore, West Bengal
Abstract: In this work investigates the anti-spermatogenic potential of the hydro-ethanol extract of Caesalpinia pulcherrima leaves (HEECPL) in male albino rats. Two groups of adult rats were created: the control group and the group that received HEECPL treatment (20 mg/100 g of body weight, orally once daily for 28 days). After completion of treatment, sperm count, motility, viability, and acrosome cap status were decreased significantly (p < 0.05), along with a decrease in acrosome cap status compared to the control. These results imply that HEECPL impairs spermatogenesis and sperm function, possibly through phytoconstituentmediated action of the extract. The study supports the possibility for the development of male contraceptive agent from C. pulcherrima as a natural and plant based effective birth control measure covering male which is not consider for this purpose like female.
Key Words: Caesalpinia pulcherrima; Anti-spermatogenic; Sperm viability; Male contraceptive